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The expression of homologous recombination (HR) genes in high grade ovarian cancer (HGOC) samples from debulking surgeries were correlated to outcomes in patients selected for chemotherapy treatment regimens.
By contrasting patterns of sequence divergence between genes in high- and low-recombination regions of the genome and by analyzing genes with and without evidence of positive selection separately, we obtained evidence that the efficacy of both positive and negative selection is higher in regions with more frequent recombination, as predicted by the HRI theory (fig. 3 and table 4).
We validated our predictions by determining the significance of our candidate genes in high throughput transcriptome expression profiling studies.
These 20 targets were displayed in two distinct clusters, indicating that methylation was associated with altered expression of these genes in high myopia individuals (Fig. 2).
Elevated DNA methylation of HR-HPV L1 and L2 genes in high grade disease has emerged as a promising molecular triage tool.
To understand the responses of Escherichia coli to high succinate stress and to determine the roles of upregulated genes in high succinate tolerance, a continuous culture of wild-type E. coli W3110 was performed for 268 days in a gradually increasing concentration of succinate.
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Although there are many similarities between genes in high-GC human isochores and high-GC3 genes in grasses, the isochore hypothesis does not fully explain the existence of high-GC3 genes in grasses: first, there is no correlation between ORFs and the flanking regions; second, most species with isochores do not have a high-GC3 peak.
Al-Shahrour, F., Minguez, P., Vaquerizas, J.M., Conde, L. & Dopazo, J. BABELOMICS: a suite of web tools for functional annotation and analysis of groups of genes in high-throughput experiments.
He said that finding the genes in high-risk families may also help researchers figure out the source of the more common cases, in which people have no affected relatives and apparently develop mutations later in life instead of being born with them.
Although many feature selection methods for classification have been developed, there is a need to identify genes in high-dimensional data with censored survival outcomes.
We detected significant up- and down-regulation of genes in high-density and low-density regions, respectively (Figure 7C).
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