HTS has been used for decades to, for example, screen for genes important for a biological process.
We identify 743 mutations distributed over 12 human genes important for intoxication by four different CDTs.
In addition, the chromosomal sites of LOH may identify genes important for lung carcinogenesis in nonsmokers.
Numerous genes important for membrane traffic and the cellular regulation of calcium, metals and other ions were upregulated.
These proteins usually bind to DNA and promote transcription of many different genes important for synthesizing cholesterol.
He is using the system to decode transcriptional programs that control genes important for neuronal differentiation and function.
The first screen was designed to identify genes important for establishment of symmetric acinar morphology, size of the structures and cell cycle restriction (Figure 1c; first screen: 1.1).
To better understand the mechanisms of curaxin CBL0137 toxicity in cancer cells, we evaluated whether CBL0137 treatment preferentially affected the expression of genes important for neoplastic phenotype.
Moreover, the regions expressed in response to differentiating stimuli were registered, giving an indication of the enhancers and genes important for SC differentiation and fusion to myotubes.
Four recent studies employed whole-genome RNAi technologies to elucidate cellular genes important for the replication of HIV-1.
The epidermal differentiation complex (EDC) locus consists of a cluster of genes important for the terminal differentiation of the epidermis.
