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The authors also reveal that four of the five genes have previously been associated with an increased risk of a range social disorders in humans, including autism.
Just a handful of recently selected genes have previously been identified, like those that confer resistance to malaria or the ability to digest lactose in adulthood, an adaptation common in Northern Europeans whose ancestors thrived on cattle milk.
Polymorphisms in interleukin genes have previously been associated with susceptibility to infectious diseases due to their influence on cytokine production.
Only two of the above-mentioned genes have previously been reported to be upregulated under submergence and dehydration in IR64-Sub1, namely the bZIP gene (LOC_Os01g36220) and the Zn-finger gene (LOC_Os07g43740) (Fukao et al., 2011).
Based on screens for mutant sensitivity against DNA damaging agents a large number of DNA repair and DNA damage checkpoint genes have previously been identified in genetically amenable model organisms.
Several genes have previously been shown to be aberrantly methylated in breast cancer (reviewed in [22]).
These genes have previously been shown to be dependent on σB for their induction [41].
Both genes have previously been shown to be essential to T cell proliferation [13], [22].
Many of the differentially expressed genes have previously been shown to display dynamic spatial and temporal expression patterns [40].
Further studies will be required to determine if these genes have previously unsuspected roles in the regulation of developmental mechanisms.
The four Arabidopsis genes have previously been reported to be expressed [11], [12], an observation that argues against this possibility.
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