The discovery of miRs as the regulators of multiple cardiac genes has added a new mechanistic link between gene regulation in the normal and failing heart at post-transcriptional level.
Two of the three other cases were the result of misannotation (PEAR1 and SPEG), and the last case (SHARPIN), one of the zebrafish genes, has added three new domains.
To illustrate the difference between disrupted expression neighborhoods of significant candidate genes and not significant genes, we have added graphs containing the queried neighborhood of the candidates (Figures S1, S2, S3).
Thus, a set of 100 genes would have added to it 100 random non-set genes and SVM performed on the association matrix among these genes and CCR measured using a full hold-out validation.
Candidate gene analyses have added a number of other genetic susceptibility loci for BD in and out of the MHC region [ 7- 11].
39 Global molecular analyses of human tumors, including gene expression profiling, have added a tremendous amount of data into the public domain.
Recent studies using high-throughput technology for gene expression profiling have added to our understanding of particulate-mediated local inflammation underlying those adverse effects on lungs and airway in response to air pollution.
Even though the study population in this microarray study is relatively homogenous (at early stages and adjuvant treatments naïve given it has been collected for validation on the 15-gene prognostic signatures), we have added one extra model using selected genes and some clinical variables as covariates to get a better control for those clinical factors.
Readers should also refer to the publications, quoted in the MS. The authors should use subtitles to clarify results and highlight interesting findings, such as " similar recombination levels between core and shell genes' Authors' response: We have added or edited subtitles accordingly.
In addition, for every gene in LeishCyc, we have added a link to the corresponding entry in GeneDB which directly connects the entries from the two databases.
