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As many cancer genes function to promote cell proliferation and/or survival, we tested whether metformin treatment might negatively effect these biological end points.
We describe a set of differentiation markers characteristic for the AIY interneuron class and show that the ceh-10 paired-type and ttx-3 LIM-type homeobox genes function to regulate all known subtype-specific features of the AIY interneurons.
Looking back over the story that links the epigenetic change of methylation in how our genes function, to the lifelong impact this can have on developmental health through stress dysregulation, to the role played by the new predator of increasing social inequality, we may begin to feel a bit overwhelmed by the seemingly insurmountable challenge this poses.
These findings suggest that in adult muscle stem cells, Pax genes function to promote population expansion, whilst maintaining commitment to the myogenic lineage.
This interpretation is consistent with the proposal that, in all animal appendages, Hox genes function to specify two developmental modules, proximal and distal, and these modules are not linked to specific anatomical landmarks [75].
Tumor suppressor genes function to regulate and block tumor cell proliferation.
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It is therefore possible that the SKSAFME domain in Dlx genes functions to control transcription of downstream target genes.
Kuboniwa, M. et al. Streptococcus gordonii utilizes several distinct gene functions to recruit Porphyromonas gingivalis into a mixed community.
Further studies of the encoded protein usually provide clues as to how this gene functions to regulate tissue growth.
Tonks, N. K. Protein tyrosine phosphatases: from genes, to function, to disease.
TSP integrates information supporting loss of gene function to calculate a single gene-specific score value that summarizes the total evidence of tumor-suppressor function for each human gene.
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