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Other statistical issues also remain open, e.g., some genes exhibit normal distributions of transcription levels before and after perturbations.
In addition, mutagenesis analyses of B. subtilis RNase H genes have shown that single-gene knockout mutants targeting the RNase HII or HIII genes exhibit normal growth, but that double-knockout mutants for both genes are unable to form viable colonies; this suggests that a functional overlap exists between RNase HII and HIII [ 31].
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However, NaV1.9 seems to be not directly involved in the generation of action potentials [35] since neurons from NaV1.9 gene knockout mice can exhibit normal action potential characteristics in RMP, threshold, amplitude and duration as shown in wild type mice [36].
Genes which receive signals from many parallel paths exhibit normal statistics while genes which lie at the end of a single pathway are prone to large statistical variations and highly skew statistics.
Overall, OmniRats exhibit normal immune development, gene usage, and physiological levels of serum antibody and respond to immunogenic stimuli equally as wild-type rats27, 28.
Regardless, Lat mice exhibit normal natural and antibody-mediated killing.
However, AC3−/− mice exhibit normal ß-adrenergic stimulation of lipolysis.
However, we identified a group of tumours with p53 gene mutations that exhibited normal or higher levels of p21 CIP1/WAF1 mRNA.
As shown in Figure 6(c), these miRNAs and genes exhibit different expression pattern in normal and tumor samples.
Unlike conserved single copy genes, the A. thaliana and O. sativa U{1 0} genes exhibit a low intron density, a normal presence of TFBS in their promoters, and they encode for proteins about 2.5 times shorter when compared to all the nuclear genes.
In other words, many genes exhibit progressive up- or downregulation of transcription across the normal mucosa → nonpolypoid → polypoid sequence.
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