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Loss-of-function mutations in several Imd pathway genes displayed increased sensitivity to CrPV infection and higher CrPV loads.
A substantial fraction of these genes displayed increased 5-mC in response to testosterone.
Transgenic plants over-expressing these genes displayed increased Al-activated root secretion of malate and/or citrate and enhanced Al-tolerance [ 2, 5, 6].
In summary, 1,397 transcripts (representing 1,281 unique genes) displayed increased expression and 1,563 transcripts (representing 1,476 unique genes) displayed decreased expression in the M. bovis-infected group relative to the control group.
Previously, BCB and GST genes were shown to be up-regulated in Arabidopsis in response to Al treatment [ 29] and plants over-expressing these genes displayed increased resistance to low Al concentrations [ 60].
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We next determined whether TSA treatment of OPCs was associated with increased histone acetylation at the promoters of genes displaying increased transcript levels.
Spearman correlation coefficients of 0.378 and −0.128 were observed for the genes displaying increased and decreased expression following infection, respectively (P ≤ 0.001).
Of the 177 genes displaying increased expression those showing the highest expression included; ERBB3, KRT18, RAB25, PRSS8, SPINT2, BSPRY, CD24, SOX4, CLDN3 and EPB41L5.
In summary, 14 genes display increased expression in response to the conditional expression of ΔNTBAR-1 and show altered expression in bar-1 (ga80 ) or pry-1 (mutant mutant backgrounds.
We observed Spearman correlation coefficients of 0.536 and −0.394 for the genes displaying increased and decreased expression following infection, respectively (P ≤ 0.001).
Previously, it has been described that L41 and Δ 9 -desaturase genes display increased transcriptional activity in hepatocytes from summer- and winter-acclimatized carp, respectively [ 43, 44].
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