(C ) Effects of I-BET151 on primary and secondary LPS-response genes (defined as per [ Hargreaves et al., 2009 ; Ramirez-Carrozzi et al., 2009 ]).
The assumption is avoided by using, in this normalization, expression levels only from no-variation genes, defined as genes that show no evidence of differential expression under a statistical test.
In neuroblastoma, the epigenetic landscape is more profoundly altered in aggressive compared to lower grade tumors and the concomitant hypermethylation of many genes, defined as "methylator phenotype", has been associated with poor outcome.
This analysis confirmed that the samples of BSE and controls were relatively homogeneous amongst themselves with regard to the genes defined as differentially regulated.
However, as group sizes were limited, gene regulation in DN of some genes defined as "false positives" can not be excluded.
A bioinformatic method was devised for the stringent prediction of 'anchor' genes, defined as a gene whose expression was restricted to one temporospatial anatomical compartment.
The set of leptospiral, pathogen-specific genes, defined as those with no orthologous gene in L. biflexa, is likely to be enriched for genes that play a role in pathogenesis.
In Table S2, we list the enriched CNS endothelial genes, defined as those GeneChip probe sets significantly enriched greater than two-fold in the endothelial:parenchymal fractions (GFP+ PDGFRbeta− GFP−).
Unless otherwise specified, we included for subsequent analysis only well-measured genes defined as those with fluorescence intensities in the Cy5 or Cy3 channel at least 1.5-fold above background in at least 60% of samples.
Perfect LD between two KIR genes, defined as r2 = 1, is reached when two of the four possible haplotypes are not observed, i.e |D'| = 1 and the frequencies of the alleles of the two KIR genes are equal.
Most famously, such denes would correspond to what are currently called non-coding RNA genes, defined as "genes for which RNA, rather than protein, is the functional end product" (Klein et al [14]).
