At least five adult-onset neurodegenerative diseases, including Huntingtin disease (HD), and dentatorubral-pallidoluysian atrophy (DRPLA) are produced by genes containing a variably increased CAG repeat within the coding region.
Plasmids expressing wild-type or mutant human MECP2 3′UTR reporter genes containing a 415-bp fragment including the most conserved miR-130a binding site (shown as the "240 site" in Fig. 4A) were constructed using psiCHECK2 vector (Promega).
Additionally we were interested in all target genes containing a motif score below 7.3.
Genes Expected Number is the expected number of genes containing a particular TFBS.
Genes Number is the number of genes containing a particular TFBS.
For each particular TFBS matrix, the fold-change in the frequency of genes containing a particular TFBS compared with a predicted background frequency is computed.
More specifically, genes containing a larger proportion of fRNAs evolve significantly more slowly at synonymous sites, independent of codon usage bias and effects of other functional variables (see Tables 1 4).
In contrast to mammals that have more than 600 genes containing U12-type introns [4], [30], the Drosophila genome has only about 20 genes containing a putative U12-type intron [30], [31], [32].
In Toxoplasma, ROP4 is a member of a large family of closely-related genes containing a kinase domain that are frequently present in multiple copies in the genome [50], [51], [52].
When RA is channeled onto the retinoic acid receptor alpha (RARα) in the nucleus, it can rapidly induce transcription of RARα-target genes containing a RA-responsive element (RARE).
Of the 173 categories, twenty-five processes were also enriched for genes containing a SNP with p<0.05 in the replication dataset, a number that is significantly greater than expected (p = 0.0045).
