Nor were they found in the promoter regions of genes, but rather in the transcribed parts of the genes themselves.
Of course Thapar knows this and, when questioned, is keen to stress that it's not just genes but rather a complex mix of genes and environmental factors that cause ADHD.
A preference for DiCaprio, though, isn't simply hormonal downtime – who you'd prefer when you're not choosing for genes – but rather an indication of preferences in the longer term.
A second puzzling feature was that many of the disease-linked SNPs did not occur in the DNA that codes for genes, but rather in the so-called junk regions of the genome.
This indicates that the high correlation obtained is not attributed to individually important genes but rather to gene groups.
It was therefore not the objective of this study to identify Pup1 candidate genes but rather to identify tolerance mechanisms and regulatory patterns affected by the Pup1 locus.
It seems that xenobiotic induction is not due to the phylogenetic correlation between the CYP genes, but rather due to the presence of the transcription regulatory site, e.g., xenobiotic response elements, located upstream of the CYP genes.
Sequence degeneracy was observed across motif sequence alignments especially in W-BOX and TATA box motifs (ESM Table 1).These are not the only putative cis-elements in the 5′ regulatory regions of OsGLP genes, but rather, they represent motifs that are present in multiple copies and are shared among family members.
The purpose of the present study was to build a genomic signature able to predict FDG uptake intensity in a diverse population of metastatic tumors, by using an unbiased gene expression profiling not limited to a predefined set of genes, but rather using whole human genome gene expression microarrays.
Conversely, if the populations we study are not well-mixed, but subpopulations exist, thus providing a distinct population structure, the traits we find to be different between individuals might not be due to the effects of a few genes but rather longer term history of evolution, separation, drifts and so on (Yatsunenko et al., 2012).
Our goal is not to identify single genes but rather global transcriptomic changes.
