The knock-in B cells bearing the H & L, H chain, and L chain genes bind gp120 with high, low, and no detectable affinity, respectively (Burton et al., 1991; Ota et al., 2013).
The expression patterns of Px-0019 and Px-0220 strongly suggest that these Papilio-specific family genes bind yellow carotenoid pigments with different spatial regulation.
Given that some PARP3 associates with PRC2, we sought to compare genes bound by PARP3 with those associated with SUZ12 or enriched for H3K27me3.
We use our data to address two general questions: What are the target genes bound by Ubx (with and without Hth) in the T3 leg and haltere imaginal discs?
In agreement with the notion that the black module found in the signed network contains genes that are implicated in pluripotency, this module is strongly enriched with genes bound by TFs in the Oct4 and cMyc groups and under-enriched for binding by Suz12.
We mapped the dE2F1 and dE2F2 peaks to the nearest genes and compared with genes bound by RBf1 and RBf2.
Then we compared the set of genes bound by a TF with the set of genes differentially expressed when this TF is knocked out.
To determine which of the Miz-1 bound genes are enriched in the H3K27me3 silencing histone modification, we compared genes bound by Miz-1 with genes previously reported to contain significant H3K27me3 in human ES cells [ 32].
Our data showed that more than 8000 hepatic genes were bound by RXRα, and 72% of them overlapped with the genes bound by RARα, PXR, LXR, FXR, or PPARα.
Exposure to DRB, Roscovitine, or PHA-767491 leads to a reduction in Ser5 RNA pol II phosphorylation which is required to promote initiation of transcription as RNA pol II moves away from the gene promoter (Kormarnitsky et al., 2000) but it is also associated with 'poised' genes bound by both Ser5 phosphorylated RNA pol II and Polycomb repressor complexes (Brookes and Pombo, 2012).
