Subsequent studies reported a total of 32 genes in the cluster, with the additional genes attributed to recent tandem duplications [ 48- 51].
The probability p is the proportion of gene models in the superset attributed with annotation Annot.
In some cases, similarities in terms of gene structures have also been attributed with biological significance [ 68].
Overall, we find that the age attribute has a strong correlation with all the other gene attributes used in this study such as tissue-specificity, gene-gene interactions, gene length and regulatory nature of genes.
The degree of genetic interaction correlates with the number of different gene attributes [ 17].
Likewise, symbiont sequences as suggested by BLAST searching (for example, GHF7, GHF5 and GHF45) all cluster with genes previously attributed to termite symbionts (not shown).
This variability may be due to genes being attributed GO terms with large numbers of parent annotations or gene/protein multi-functionality.
An activated WNT pathway gene signature was attributed to tumors with significant (P < 0.05) upregulation of WNT pathway gene signature expression relative to the rest of tumors within each breast cancer cohort; a Fischer exact test was used for this calculation.
Data on drugs or compounds and their known targets (and where available their mechanism of action) was downloaded from the Drugbank Database (v3.0) [ 58] and mapped onto our network using the gene name attributes associated with both drug targets and proteins.
These functional attributes are tissue specificity (TS), transcription factors (TFs), post-translation modifications (PTMs), protein kinases (PKs), secreted proteins (SPs) and whether the protein is a hub in the interactome, with node connectivity greater than four (i.e. node connectivity > = 5) along with the gene attribute of methylation (METH), in cancer vs. non-cancer associated genes.
The short length of human housekeeping genes, compared with tissue-specific genes, has been attributed to selection for economy in transcription and translation.
