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CRISPR enables functional experiments in cell lines and model organisms to validate candidate genes arising from genetic studies.
If so, these genes are putative homeologs or ohnologs – duplicated genes arising from polyploidization events [46].
Genes arising from the syngenic tumor dataset were clustered using the technique described in [13].
Potentially, many of these miRNA candidates represent species specific miRNA-like genes arising from recent duplication of progenitor sequences [3], [4].
We can thus conclude that common variation in INSIG2 and PFKP, both candidate genes arising from GWA studies, do not play a significant role in the pathogenesis of obesity in the Danish population.
The data contains peaks intensities for two genes arising from an MLPA assay.
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Given this tree (Figure 2), the most parsimonious interpretation is that all current interferon lambda genes arose from a single interferon lambda gene in an ancestral species.
The results indicated that oxygen-responding genes arose from ohnologs more frequently than from non-ohnologs (Supplementary Table S2-B) in the evolution of the S. cerevisiae genome.
For example, evidences support that the RAG1 and RAG2 proteins that carry out V(D J recombination of immunoglobulin genes arise from domestication of DNA transposons protein [8].
Third, phylogenetic analyses imply that the A-myb and C-myb genes arose from a B-Myb/Dm-Myb-like ancestor by two gene duplication events that included the acquisition of a unique transcriptional activation domain [6].
As it is clear that the cyclostome genomes have experienced at least one WGD –the event during which Shh/Ihh and Dhh genes arose from the ancestral Hedgehog gene [41], we favour the second possibility for two reasons.
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