A Gene Ontology (GO) term enrichment analysis showed that tissue-specific genes are enriched with GO terms reflecting the physiological functions of the specific tissue, and housekeeping genes are enriched with GO terms related to essential biological functions.
The importance of the study has been illustrated by the enrichment analysis and observed that direct interaction and associated genes are enriched in viral entry into host cell.
GO enrichment revealed that the target genes of these DH genes are enriched in adaptive immune pathways.
We show that SNPs within genes are enriched for association signals.
We found that downregulated genes are enriched for genes involved in reproduction and that upregulated genes are enriched for genes involved in somatic development, especially neuronal development (Supplementary Fig. 2b, c).
Jeffries, A.R. et al. Random or stochastic monoallelic expressed genes are enriched for neurodevelopmental disorder candidate genes.
Similarity, the up-regulated genes are enriched for neuronal related diseases, including: oligodendroglioma, multiple sclerosis, astrocytoma, and large cell neurocarcinoma.
It has been reported that long Arabidopsis genes are enriched for genic DNA methylation especially toward the 3′-end31,32,33.
In non-loaded aged bones, down-regulated genes are enriched for MAPK, Wnt and cell cycle components, including E2F1.
Essential genes are enriched in genomic regions with inherently low expression noise, supporting the hypothesis that chromosomal clustering of essential genes results from selection against their expressional stochasticity.
CONCLUSIONS Putative PAX8 target genes are enriched for common SOC risk variants.
