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Model coefficients for individual genes are converted into IQRR in Fig. 3c and plotted on a log scale.
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For multiple regression analysis, allelic variation of the six genes was converted to dummy variables.
In a strain lacking RF-1, phosphoserine phosphatase, and where seven UAG codons residing in essential genes were converted to UAA, phosphoserine incorporation into GFP and WNK4 was significantly elevated, but with an accompanying loss in cellular fitness and viability.
The status for all genes was converted into trinary scores (present = 2; divergent = 1; highly divergent or absent = 0).
These genes were converted into human genes using HomoloGene (build 62) and taking into account only the mouse genes with a unique homologene human ortholog.
Rat genes were converted into orthologous human genes by using a mapping table provided by the Jackson laboratory (http://www.informatics.jax.org/).org/
Therefore, all genes were converted to human Entrez identifiers.
Wherever available, non-CG number genes were converted to CG numbers mainly using BDGP.
For ACSEA, annotations for each interacting pair of genes were converted to logic statements.
Then, using the "orthologues" function, murine genes were converted into their human counterparts.
Sheep gene symbols with 21,865 genes were converted into human gene symbols with 15,343 using BioMart in R package [ 61].
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