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Trans-acting regulators provide novel opportunities to study essential genes and regulate metabolic pathways.
MicroRNAs (miRNAs) are encoded by endogenous genes and regulate primarily at the stage of translation over half of all genes in mammalian cells.
Moreover, the endophyte could modify the expression of drought responsive genes and regulate antioxidants.
They can bind to the cis-acting element in promoters of their target genes and regulate expression of downstream stress-responsive genes in drought and salt stress signal transduction (Zhu 2002; Yamaguchi-Shinozaki and Shinozaki 2006).
Then, the complex will activate the transcription of target genes and regulate specific functions including biofilm formation, bioluminescence, the secretion of virulence factors, and sporulation (Davies et al. 1998; Greenberg et al. 1979; Nealson et al. 1970).
miRNAs target a multitude of genes and regulate cellular physiology through different mechanisms.
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In rice, OsMYB61 is a key regulator that binds to the promoter of CESA genes and regulates their expression (Huang et al., 2015).
These findings demonstrate that MUC1-C interacts with p53, occupies promoters of p53 target genes and regulates p53-dependent transcription.
The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.
RNA interference (RNAi) is an evolutionarily conserved cellular defense mechanism that protects cells from hostile genes and regulates the function of normal genes during growth and development.
PPAR gamma activates the expression of many genes and regulates glucose homeostasis, insulin sensitivity, lipid metabolism, immune responses, cell fate and inflammation [37 39].
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