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Application of RMT to large-scale biological data sets allows for grouping of functionally related genes and functional prediction of unknown genes.
After obtaining the low-dimensional vector representations of both genes and functional labels, we use these vectors to predict gene function.
The major advantage of a function-based screening approach is that only full-length genes and functional gene products are detected.
Because modeling the complex relationship between genes and functional labels with a single transformation matrix may be overly restrictive, we group functions into different clusters and learn a separate projection model for each cluster.
Geisheker MR, Heymann G, Wang T, et al. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains.
We focus on the identification of metastasis genes and functional characterization of their involvement in tumor-stromal interactions during the formation of metastasis in different organs.
The resulting liability index can be used as the core phenotype for subsequent analyses searching for specific causal genes and functional genetic variants of relevance to psychiatric disease.
The transgenic plants also accumulated higher levels of drought-related regulatory genes and functional gene transcripts, including those of PIP, NAC, RD22, ABI, and NCED.
MOTIVATION: Linking genes and functional information to genetic variants identified by association studies remains difficult.
Coincident loss of CDKN2 genes and functional Rb protein was rarely observed (in two of 135 cell lines).
Prediction of putative target genes and functional annotation implied that these altered miRNAs affect many target genes mainly involved in PI3K/Akt signaling pathway.
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