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Yao Y, Richman L, Higgs BW, Morehouse CA, de los Reyes M, Brohawn P, et al. Neutralization of interferon-α/β-inducible genes and downstream effect in a phase I trial of an anti-interferon-α monoclonal antibody in systemic lupus erythematosus.
In total, 51 genes including PIPK, PIP (plasma membrane intrinsic protein), CaM genes and downstream transcriptional regulator (HSF) genes involved in the ability of plants to sense heat52 showed differential responses to heat stress between TM-1 and Hai7124 (Supplementary Tables 41 and 45).
This is because once a loss of function mutation occurs at any regulatory locus of a signaling pathway, mutations in its member genes and downstream FGUs may be relieved of selection pressure, except those having multiple functions.
Candidate genes in the QTL intervals include photoreceptors as well as several circadian clock genes and downstream components.
A gene expression microarray identified MMP-1 and uPA as potential STAT6 target genes and downstream modulators of cell invasion.
Similarly, previous modeling studies proposed that connections between regulatory genes and downstream gene perturb oscillation dynamics [ 20].
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Each overlap id leads to a detailed new page of the overlap including five labels that provide: overlap information, upstream gene information, upstream gene sequence, downstream gene information and downstream gene sequence.
We show that in ERα-positive breast cancer cells (MCF-7) the estrogen receptor gene and downstream target genes are cell cycle regulated with expression levels varying as much as three-fold between phases of the cell cycle.
This web based program returns the sequence of the upstream non-coding region, gene, and downstream non-coding region along with the associated annotation for any gene (References: NCSRS - PMID: 17362514 LAGAN - PMID: 12654723).
The pSTCII-GFP plasmid expresses GFP under the control of the upstream untranslated region of the P. yoelii chloroquine resistance transporter (PyCRT 5') gene and downstream untranslated region of the P. vivax actin (PvAc 3') gene.
Analysis yielded a 250.2 kb (51 SNP) shared segment over the RET gene (and downstream) in only those patients with the mutation with no similar segments found among other patients.
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