In human development, certain genes act as master switches, ensuring that we are born with similar attributes (one head, two lungs, 10 fingers) in nearly all circumstances.
Mr Gehring has evidence that the two interchangeable genes act as master switches which activate at least 2,500 others whose interplay ultimately determines that development.Will we ever be able to unravel these genes' labyrinthine workings?
It is likely that these genes act as biomarkers for hepatocellular carcinoma therapy.
These observations suggest that the three Runx genes act as functionally redundant oncogenes in T-cell lymphoma development.
Notably, the above-mentioned pollen sterility genes act as gametophytic pollen killers, whilst the LTMS gene identified in our study acts as a sporophytic pollen killer.
This unexpected result supports the view that an important part of the modulated genes act as upstream or downstream effectors of STAT5.
The level of iPRMP was increased in the AtSOFL1- and AtSOFL2-overexpressing transgenic plants, but decreased in the SOFL1-RNAi62 sofl2-1 double mutant (Table 1, Table 2, Table S3), suggesting that the products of these two genes act as positive regulators of the endogenous level of iPRMP.
The impact of adaptive evolution on parasite biology stems from the premise that the fixation of duplicated genes is an adaptive event; that these duplicated genes act as a source for protein subfunctionalisation [12] by evolution of key positions in the protein, and that this adaptation is reflective of organism-specific selective pressures.
In vitro up-regulation of CHSA and CHSB was due to an indirect interaction between the ecdysone receptor complex and ecdysone-responsive elements within the CHSA and CHSB promoters in D. melanogaster and these two genes act as members of the late genes [18].
Tumor suppressor genes act as recessive determinants of cancer.
It is known that co-regulated genes act as a hindrance to genomic rearrangements.
