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Some generic preparations have been approved because of pharmacological effects (e.g., decrease of serum uremic toxin in rats) similarities with those of the original product, according to the BE guideline available at the time.
We would not recommend unmonitored switching between different generic preparations.
Currently there are no generic preparations available for ciprofloxacin in South Africa.
Research in different branches of medicine raise various views regarding the use of generic preparations.
Since expiry of the tacrolimus patent in 2008, generic preparations have become available and have been widely adopted.
Since the expiration of the patent for Prograf®, generic preparations have been approved in Europe as bioequivalence has been shown in healthy volunteers.
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As a control, two monkeys received a generic preparation of antibodies and two others received antibodies that in test tube studies can prevent infection with a virulent SIV strain.
Another potential explanation is that each study compared a different generic preparation with Prograf.
This latter finding is not unexpected since more intensive monitoring would be likely following conversion to a generic preparation or other changes in the immunosuppression regimen.
In 2011, the cost per unit of insulin was twice as much for an analog compared with a generic preparation (2).
If the price of the cheaper generic preparation of DMPA had been used in the calculation, the savings would have been greater.
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CEO of Professional Science Editing for Scientists @ prosciediting.com