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Several mechanisms have been postulated to explain the association, some of which might be particular to MS, but others would be expected to cause a more generic predisposition to autoimmunity.
On the other hand, both the hypothesis that EBV immortalises self-reactive B cells that would otherwise be deleted [ 15] and the idea that EBV resets the global immune system to a more active state [ 16] imply that EBV infection should cause a generic predisposition to autoimmune disease, which is difficult to reconcile with the findings of the present study.
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Should a genetic predisposition influence sentencing?
A possible genetic predisposition to disease.
So far no genetic predisposition has been found.
"I think there are a subset with a genetic predisposition".
The fact that TERT rs2736100_C predisposes to all MPN subtypes implies a generic role in MPN predisposition, possibly through affecting blood cells counts.
Given that REST (NRSF) is involved in suppression of genes that are required for differentiation of embryonic and adult stem cells [24], the age-induced hypermethylation of REST-targets, if confirmed in a stem-cell population, may represent a generic mechanism for age-associated loss of stem-cell function and increased predisposition to cancer [5].
Although marginalized by newer, more powerful, and more advertised statins, pravastatin could serve as a valuable alternative, especially for patients with a predisposition for DM; the lower price of the drug (being now available as a generic) could also increase the cost effectiveness of medicating the low-risk population.
"... (E vidence that merely indicates a generic inclination to act within a broad range, not all of which is criminal, is of little probative value in establishing predisposition", he wrote.
True? – Family predisposition & genetic statement?
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com