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But such reorganisations are usually more of a trade-off than an unambiguous win: splitting up organisations can bring a tighter focus, with clearer objectives; but it can also reinforce another generic failing of government, the tendency to operate in silos.
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There are both particular and generic failings that have allowed these tensions to develop.
The MIDAS was developed in response to generic instruments failing to measure aspects of myocardial infarction (MI) specific to this patient group e.g. confidence and lifestyle changes [ 1].
Now the court has also held that consumers cannot sue generic manufacturers for failing to design a safer drug because the generic must be chemically equivalent to the brand-name drug.
Mutual appealed to the Supreme Court, which ruled in 2011 that patients could not sue generic manufacturers for failing to warn them adequately about drug risks because, under existing laws and regulations, the generic makers cannot unilaterally change warning labels.
"This does not mean that malls as a generic type are failing," said Anthony Downs, senior fellow at the Brookings Institution and a director of General Growth Properties, a leading owner and manager of malls.
Dozens of suits against drug companies have been dismissed in federal and state courts because of a decision by the Supreme Court last year that makes it virtually impossible to sue generic manufacturers for failing to provide adequate warning of a prescription drug's dangers.
One million bugs per gram of tissue left alive by the failing generic could increase its chances of selecting resistant mutants, making resistance a theoretical possibility [ 24].
If gentamicin products are compared with the innovator using only the dose-response curves obtained during the experiment in which generic was studied, 3 more generics would appear failing in vivo, for a total of 13.
Although establishing mechanisms to address relative importance and redundancy within patient questionnaires are not easy, the alternative is to bypass the problem by failing to measure generic outcome in primary care and therefore to be unable to assess the benefits for patients of alternative models of provision of primary care.
Some state attorneys general and pain treatment experts had also urged the F.D.A. to block the release of generic versions of OxyContin, arguing that failing to do so would feed street demand for strong narcotics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com