Multiple combinations of LGR4-6, Rspo1-4 and ZNRF3/RNF43 are possible, implying the existence of generic interaction determinants, but also of specific differences in complex architecture and activity.
We have identified the generic chemical determinants responsible for the GAG-mediated acceleration of amyloid fibril formation, and have used this knowledge to build a predictive equation of the effect of GAGs on protein aggregation.
Therefore the approach typically identifies highly specific virulence factors with limited extrapolation to generic virulence determinants of other pathogens.
The presence of KerV orthologs in defined genomic context in other important pathogens suggested that KerV might represent a type of generic virulence determinant.
Previous studies have investigated the determinants of generic travel plans but lacked an appreciation of the unique context of healthcare settings.
This paper argues that many determinants of generic oligopoly market outcomes can be studied in bid-based wholesale electricity markets under much weaker assumptions than in other oligopoly industries because of their rich data, regulatory history, and clearly specified market rules.
The determinants of generic substitution are numerous.
In a clearly defined convenience sample of outpatients with stable systolic chronic heart failure (CHF), we could explore determinants of generic and disease-specific health-related quality of life (HRQOL) using a wide set of explanatory variables.
Given there is little evidence for patients with CHF recruited in primary care, our aim was to identify and explore the impact of determinants of generic and disease-specific HRQOL with respect to a wide set of individual and provider variables.
The huge interregional differences indicated that prescribing behaviours and beliefs are probably the main determinant of generic substitution.
