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Built in the 13th century, the Bargello was a palace-turned-prison that witnessed generations of trials and executions.
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The plants have been 'pre-screened' through generations of trial and error processes occurring over hundreds or thousands of years [ 5].
Such information represents the key to unlocking the potential of this approach, to inform the next generation of trials of IGF signalling inhibitors.
In this review article, we address the radiation oncology process improvements in clinical trials and review how these changes improve the quality for the next generation of trials.
The International Breast Cancer Study Group (IBCSG) opened its first generation of trials in 1978.
They expressed the belief that the dose of platinum would continue to be investigated within this new generation of trials.
In the second generation of trials, initiated once the taxanes became regarded as the 'gold standard', taxanes were included in all comparator arms.
We will outline the issues the first generation of trials are designed to address as well as questions that must be addressed by future studies.
Therefore, a second generation of trials was planned to define further the best taxane, the optimal schedule of administration, and whether the addition of further agents might be of some benefit.
Correlative science studies such as these are an important aspect of this generation of trials because they provide an opportunity to move our field beyond the pure empiric approach of earlier eras.
The number of patients enrolled in the recent generation of trials has been in the 4,000 to 7,000 range, which is many times greater than was the case when the EBCTCG was formed several decades ago.
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