Generation of excessive free radical is considered the cause of apoptosis and DNA damage [36, 37].
It has some other drawbacks such as generation of excessive sludge and the problem of sludge disposal into the environment.
No, not ritzy holidays and the like, but being there in the present for yourself and your family without the intrusions of the perennial stresses attached to the generation of excessive wealth.
We have previously demonstrated that neuronal m-HKI reduces hyperglycemia-induced generation of excessive ROS through an ADP recycling mechanism [8].
Hyperglycemia and insulin resistance contribute to the generation of excessive ROS/RNS which have damaging effects on myocardial function.
Such deficits may lead to generation of excessive reactive oxygen species (ROS) and oxidative damage, clearly implicated in several neurodegenerative diseases, or to depletion of ATP [ 7, 8].
The consequences of impaired intracellular redox balance includes the generation of excessive RONS, induction of lipid peroxidation, DNA and protein damage, depletion of intracellular stores of endogenous antioxidants and inhibition of antioxidant enzymes [ 4].
On the other hand, the repair process involves the orchestration of several different intestinal mucosal cell populations that, during chronic and persistent tissue damage, may result in the generation of excessive connective tissue deposition and the development of fibrosis.
However, clinical concerns have arisen over the generation of excessive peri-prosthetic strains, which may be associated with subsequent fractures, and polar gaps, which may serve as route for wear particles or obviate bony ingrowth.
These studies have shown a major role for ion channels in the generation of excessive and hypersynchronous neuronal discharges (the so-called paroxysmal depolarizing shifts), a hallmark of the epileptic activity.
