Sentence examples for generation viruses from inspiring English sources
Further, most oncolytic adenovirus trials completed have utilized early generation viruses, which are rather attenuated in their replicative potential.
(5) In addition, recently conducted clinical trials have shown the impressive therapeutic potential even with early generation viruses.
Engineered adenovirus (Ad) was used in early CF clinical trials 11 but at high titers, some of these reported significant inflammatory responses and unacceptable toxicity; this problem has largely been overcome with the use of new generation viruses.
To test the feasibility of the ARCA technology, the prostate-specific enhancer (PSE) fragment was engineered into the adenovirus genome and generated a first generation virus, CV706.
For expression of Sec61α/γ complexes, a 100 ml culture of cells at 0.5 × 10 cells/ml was infected with 2 ml of first generation virus (V1), which resulted in immediate arrest of cell growth.
These "second generation" virus-based systems also can retain larger foreign coding sequences and thus produce larger proteins in plants [ 34], here we produced enzymatically active 56,000 MW E1.
Unfortunately, when an advanced generation virus that lacks all viral coding sequences was introduced into the supporting cells of the cochlea, loss of hearing was still reported indicating enduring ototoxicity [ 149].
These next-generation viruses are called "vandals" and are essentially mini-applications, which are written in software languages like Java and ActiveX.
This technical repeat therefore only quantifies variation associated with sample preparation and sequencing, whereas the biological replicates also quantify variation associated with the processes of codon-mutant library creation, virus generation, and virus passage.
Antibiotic-treated SPF mice given a sub lethal dose of PR8 virus had impaired generation of virus specific antibody, cluster of differentiation 4+ (CD4+) and CD8+ T cell responses and delayed viral clearance 16.
