Reactive oxygen species are, in fact, general mediators of cell damage (Kehrer, 1993) and their generation is a prerequisite for the triggering of cell death by several stimuli, including growth factor withdrawal (Palazzotti et al, 1999) and activation of the tumour suppressor protein p53 (Polyak et al, 1997).
Systematically quantifying the greenhouse gas (GHG) emissions of biomass power generation is a prerequisite for robust decision-makings associated with the technology's scale deployment.
Intracellular ROS generation is a prerequisite for photodynamic cell killing.
However, it is inaccurate to assume that ROS generation is a prerequisite to NP-induced toxicity since a few studies have reported the direct toxicity of NP without causing ROS [ 19].
This oxidising environment is a prerequisite for generation of disulphide bridges within proteins such as scTCRs [ 56, 57].
Specifically, TGF-β1 significantly induced expression of SRp20, and reduced the expression of SRp30C, which has been suggested to be a prerequisite for generation of alternatively spliced fibronectin.
Prerequisites for the generation of effective immunoconjugates are antibodies which efficiently deliver the respective cytotoxic payload.
As prerequisites for the generation of appropriate disease models by genetic engineering, pigs show suitable reproductive performance traits, a high-quality draft pig genome sequence is available, and efficient and precise techniques for the genetic modification of pigs have been established.
As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established.
It is generally accepted that correct protamine loading is a prerequisite for the generation of competent spermatozoa and thus essential for full fertility in mammals, including humans (Baarends et al., 1999; Cho et al., 2001; Prakash, 1989; Steger et al., 2003).
