Sentence examples for generation of variants from inspiring English sources
The pig and human-pig chimeric α-chains can serve as blueprints for the design of a new generation of variants of α-chain(s) suitable for the gene therapy of sickle cell disease.
In mutagenesis, TPCR is primarily advantageous for generation of combinatorial libraries of targeted mutants but could be also applied to generation of variants with specific multiple mutations throughout the target gene.
They contrast their view with the meme based account of cultural evolution presented by Dawkins and Blackmore (e.g., Blackmore 1999), and argue that focusing on replication and selection rather than on the generation of variants and on reconstruction processes is particularly harmful for understanding cultural evolution.
The immunoglobulin genes use the 7 bp and 9 bp repeats for generation of variants through VDJ recombination [ 33].
The study has available the data to test the "real genetic variation" vs. "rapid generation of variants" hypotheses.
Several of these changes occur at the level of alternative splicing, with the generation of variants that promote multiple aspects of tumorigenesis.
These findings led us to hypothesize that quail could play an important role as intermediate hosts that permit adaptation of influenza viruses from wild aquatic birds and the generation of variant viruses that can cross to other species, such as chicken, pigs, or humans.
This resulted in repeated generation of variant (non-Pro-rich) HyPRPs with diverse expression patterns.
We have discussed ongoing community efforts to address these challenges, including clinical-grade sample collection, digitalized phenotyping, acquisition of high-quality sequencing data, rigorous generation of variant calls, comprehensive functional annotation of variants, and biological validation of variant function.
In particular, we urge the need for clinical-grade sample collection, high-quality sequencing data acquisition, digitalized phenotyping, rigorous generation of variant calls, and comprehensive functional annotation of variants.
Web-based interfaces such as Galaxy streamline the generation of variant lists but lack flexibility in the downstream annotation and filtering that are necessary to identify causative variants in medical genomics.
