Exact(3)
It should be emphasized that the available evidence [15], [16], [18], [51], [53], [54], together with the presents results, indicate that loss of apical-basal polarity (including loss of adherens junctions) is necessary, but may not be sufficient, for the generation of progenitors that divide, in an abventricular location, symmetrically into two neurons.
Cortical development relies on a fine-tuned balance between the generation of progenitors and neurons.
VEGFR3 activity is therefore not necessary for NSC maintenance but required for the generation of progenitors and neuroblasts, suggesting that VEGF-C/VEGFR3 signaling regulates activation of cell division in NSCs.
Similar(57)
In contrast to the orderly transition of normal stem cells through differentiation with generation of progenitor and terminally differentiated cells, multistep carcinogenesis is likely to generate heterogeneity in cancer-initiating population, which is reflected in different cell surface markers that identify cancer stem cells in different tumor types.
For this, we initially focused on the generation of progenitor cells along the dorsoventral axis at E10.5.
When we compared ATF2 knockout and heterozygous embryos for the generation of progenitor cells at E10.5, we did not observe any significant differences in the expression patterns of these transcription factors (Figure 3A).
Unlike Wnt, which promotes the generation of progenitor cells, we assume that BMP suppresses the production of progenitor cells by inhibiting the replication probability of the progenitor cells.
It has been observed that ESWT applied to bone marrow promotes the generation of progenitor cells (Wang et al 2002; Schmidt et al 2007; Yang et al 2007).
Next to acute vascular haemolysis of infected erythrocytes during acute malaria, both acute and chronic infection cause inflammation resulting in dyserythropoiesis due to changes in iron storage metabolism and cytokine-mediated suppression of the generation of progenitor cells [ 24- 26].
Mammary stem cells, defined by indefinite self-replication that ensures tissue self-renewing by asymmetric cell division and generation of progenitor cells, have been isolated from both normal breast tissues and breast tumors [ 10].
After eight generations of progenitor strain inbreeding, the MA lines were propagated for 250 generations under single-hermaphrodite bottlenecking across generations in benign laboratory conditions as previously described (Baer et al. 2005).
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