Exact(5)
Generation of new bone was studied by gross inspection, radiographs, and histological examination.
Key features of bone tissue structure and composition are capable of directing cellular behavior toward the generation of new bone tissue.
Temperature-dependent polymerising polyethylene oxide hydrogel was used as a vehicle to deliver bone marrow mesenchymal cells by injection in six nude mice, four mice acting as controls, to study generation of new bone in the cell hydrogel complex.
These insights bring us much closer to understanding the mechanobiological environment and stimuli that stimulate the proliferation and differentiation of periosteum-derived progenitor cells and ultimately drive the generation of new bone tissue.
In conclusion, we have shown that graphene-coated surfaces are biocompatible and that the topography of the graphene coating can have a profound influence on the long-term behavior of cells, in particular the cellular differentiation and mineralization process involved in the generation of new bone (osteogenesis).
Similar(55)
Autogenous bone graft is considered as gold standard among these grafting materials; however, its limitations include morbidity of donor sites, delay of new bone generation, and complications such as material infection and sinusitis [3, 4].
Formation of new bone surrounding the implant was observed.
Six of the drugs inhibit bone breakdown and one spurs the growth of new bone.
Morphometric analysis of new bone formation (B) and local bone mineral density (C).
Figure 11: 3D reconstruction micro-CT images of new bone formation within the femoral bone tunnel.
The physical stress placed on bones during exercise stimulates the growth of new bone tissue.
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