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The stress induced changes in gene expression in turn may participate in the generation of hormones like ABA, salicylic acid, and ethylene.
The altered microbial community may in turn benefit plant Fe acquisition via production of siderophores and protons, both of which improve Fe bioavailability in soil, and via generation of hormones that trigger the enhancement of the plant's Fe uptake capacity.
DOI: http://dx.doi.org/10.7554/eLife.05615.002 Adipose tissue is a major storehouse for excess energy and has recently been shown to be an endocrine tissue critical for the generation of hormones and cytokines involved in energy metabolism (Galic et al., 2010).
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These series of events, expression and posttranslational modification of PRL, and subsequent secretion by exocytosis resemble the generation of other hormones generated from a prohormone.
Alternatively, the development of SERMs/SERDs lacking cross-reactive agonism towards GPER could represent the next generation of anti-hormone therapy.
Collectively, these emerging studies strongly support the concept that CDK2 activity is a critical component for the generation of a hormone therapy-resistant phenotype and that blocking of CDK2 activity may be useful as a therapeutic strategy for therapy-resistant patients.
Parallel examples are the generation of the adrenocorticotropic hormone (ACTH) and it's related peptide hormones generated in the corticotroph cells of the adenohypophysis by proteolytic cleavage of their precursor proopiomelanocortin (POMC) (105) and the thyroid hormone axis (TRH, TSH, T4/T3), where the bioactive T3 is processed from T4 by local deiodinases at the target tissue level.
The later generations of hormonal contraceptives contain lower doses of estrogen and progestin, as well as newer combinations of the hormones [ 20].
NEUROG3 is a key regulator of pancreatic endocrine cell differentiation in mouse, essential for the generation of all mature hormone producing cells.
Measurement and exogenous application of plant hormones and the generation of mutants with altered hormone levels have determined both the inhibitory and promoting effects of auxin in controlling apical dominance [ 35].
Rabeler, R. et al. Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism.
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