Sentence examples for generation of compound from inspiring English sources

Compounds can be downloaded in one of four different file formats (Mol2, PDB, SDF and SMILES) with the generation of compound 3D coordinates from SMILES done using CORINA.

Continued development of the ChEMBL-RDF scripts, however, has started using RDF libraries for this purpose specifically for triple generation of compound names, removing code in the scripts to escape special characters, like double quotes.

To do this, the effect of combined deficiency of STAT5 and Gab2 on hematopoiesis was tested following generation of compound mutant mice.

Generation of compound mice that carry in addition to RAF other transgenes that encode proteins modulating signaling pathways frequently altered in human NSCLC allowed us to unravel two key steps in the process of metastasis, induction of the angiogenic switch and progression to micrometastasis associated with reprogramming of intestinal selector genes [11].

In the well-accepted mechanism for dioxygen activation in P450 monooxygenases, two protons (and two electrons from NADPH) are required for generation of Compound I [ 27].

The generation of compound transgenics by crossing the R26 LacZ−stop−Met mice with available cre-lines will offer a unique genetic setting for determining tissue-specific sensitiveness to enhanced Met signalling either during development, in adulthood, or in pathologies.

A fragment-based approach to multi-target drug discovery could lead to a new generation of compounds with improved physicochemical and pharmacokinetic properties.

Attempts to optimize further the potency of inhibitors by preparing a second generation of compounds did not result in structures with greater potency than that of the 3,4-dichlorophenyl analog from the first generation.

These findings may also apply to other polycyclic xanthone antibiotics, and they form the basis for genetic engineering of the xantholipin and similar biosynthetic gene clusters for the generation of compounds with improved antitumor activities.

In order for medicinal chemists to tune solubility of lead compounds, a rapid assay is needed to provide solubility data that is accurate and predictive so that it can be reliably used for designing the next generation of compounds with improved properties.

In view of these results, and in order to get deepen insight into the molecular aspects at the base of the transport mechanism, a second generation of compounds, based on 6-bromo-6-deoxy-l-ascorbic acid (BrAA) as the carrier molecule was designed and synthesized.