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We generated the labeled pairs by using the procedure described in the Automatic generation of class labels for concept pairs section with different values for the variable min_support and for the variable margin.
While adoptive immunotherapy with T cell lines for Type III EBV malignancy (such as posttransplant lymphoma, PTLD, which expresses the immunodominant EBNA-3 antigens) has been used to prevent and treat PTLD, the generation of class I MHC-restricted CTL suitable for the immunotherapy of Type II EBV malignancy is difficult.
The use of thiol- and triazole-based cross-links and the peptide-stapling technique for the generation of class A helix mimetics were evaluated to overcome the limitations regarding cellular permeability and proteolytic resistance.
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So far, humanized mouse models based on the transplantation of human HSC only – i.e. without additional human tissues – share these limitations, and immunization strategies result in the limited generation of class-switched antigen-specific B cell responses [14], [31], [32].
HCA is considered more robust in the generation of classes than PCA due to inclusion of additional dimensions [25], [31] and correctly grouped 86 of 90 samples, with only 4 spectra from II-3 improperly clustered with FH (Figure 3B).
Studies in mice have demonstrated synergistic effects of BCR and interferon signals in activating low-affinity B cells and generation of class-switched antibodies [ 96].
Aside from B cells, which produce these autoAbs, and CD4+ T cells, which provide B cell help for the generation of class-switched, affinity maturated autoAbs, essentially every other immune cell subset has been implicated in SLE pathogenesis.
PI103 is a second generation inhibitor of class I PI3K with anti-tumour activity in a variety of human cancers [ 14– 16].
We note that M K ( 2 ) ( 1, 0 ) = M K (see [4]), so the class M K ( k ) is a generation of the class MK.
Chairman Mao practiced an exclusive form of collectivism, not through "harmony" but through a generation of murderous "class struggle".
Else K → K + 1 and Goto 1. Once the generation of new class representatives terminates and the set of CRs has converged around the clustered regions of string space, the class elements are evaluated.
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