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Their osteogenic differentiation further offers the possibility of directed generation of bone constructs.
This paper explores the use of selective laser sintering (SLS) for the generation of bone tissue engineering scaffolds from polycaprolactone (PCL) and PCL/tricalcium phosphate (TCP).
The surface modification of biomaterials is extensively recognized as a key strategy in the design of the next generation of bone implants and tissue engineering.
We have conducted a systematic screening of several variables that may affect generation of bone via adenoviral gene therapy vector delivery, on image-based designed and solid freeform-fabricated scaffolds.
However, the interplay between mechanics and biology in de novo generation of bone in postnatal defects as well as healing of morcellized bone graft or massive cortical bone autografts is less well understood.
Owing to the structural similarity to natural bone, nanotopography created on Ti bone implant surfaces will lead the next generation of bone implants that possess high integration to the biological environment and promote better healing for dental and bone tissue engineering applications.
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Vascular leak studies and generation of bone-marrow chimeric mice were performed as previously described [ 22].
Generation of bone-marrow-derived macrophages (BMDMs) followed the protocol from the original report (Munder et al., 1999).
These results demonstrate the feasibility of silk-based implants with engineered bone for the (re- generation of bone tissues and expand the class of pre- generationofe-implant materials with a mechanically staboneand durable optissues
These findings open the door for researchers to develop a new generation of cortical bone scaffolds that can restore strong, organized bone.
The results of this work lead us closer to the development of bone-like collagen HA composites that could become the next generation of synthetic bone grafts.
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