Sentence examples for generation of affected from inspiring English sources

Generation of affected KEGG pathways (Kyoto Encyclopedia for Genes and Genome, Kyoto University, Japan) used Pathway-Express, a web-based tool freely available as part of the Onto-Tools (http://vortex.cs.wayne.edu) [42].

In 11 (26%) kindreds, the most recent generation of affected subjects had an age of onset >10 years younger than the previous generation (Supplementary Fig. 1).

Studies have observed that the most recent generation of affected individuals in some families had symptoms at least a decade earlier than those in the previous generation [ 34, 36].

American scientists have attempted to modify the DNA of human egg cells using a new gene-editing technique that could eliminate inherited diseases from subsequent generations of affected families, The Independent can reveal.

Females are less affected, as are earlier generations of affected family members [1].

These diseases are characterized by genetic anticipation, the increase in severity of the disease, and decrease in age of onset in subsequent generations of affected individuals.

All three mutations were found along three consecutive generations of affected family members and were not detected in 200 normal chromosomes.

Several families with multiple generations of affected individuals have recently been identified, which suggests there may be an underlying genetic propensity for cholesteatoma [ 48, 49].

There is strong evidence that the frequency of mutations in BRCA1 or BRCA2 genes is increased in women with a strong family history of breast and/or ovarian cancer involving multiple generations of affected blood relatives and/or those with a specific ethnicity or from certain geographical locations that are associated with known founder mutations.

These findings could be highly relevant when analyzing data from next generation sequencing of affected family members.

Intriguingly, autosomal-dominant DKC patients show anticipation, that is, symptoms of a disease are manifested at earlier ages in later generations of one affected pedigree.