Importantly, the force generation defects we observed here were in non-hypertrophic cells, suggesting a primary event not consequential to hypertrophy and related maladaptive processes.
Future experimentation in the neb zebrafish, using, for example, nebulin rescue constructs defective in either thin filament length determination or else regulation of cross-bridge kinetics, will be instrumental in the resolution of these and other questions related to NM, especially given how well neb zebrafish recapitulate the force generation defects observed in patient myofibers.
The generation of defect clusters in the matrix and precipitates slightly increased the indentation hardness, while disordering of the submicron-sized γ′ precipitates resulted in a dramatic decrease in the total hardness, which decreased further during the early stages of the intermixing between γ′ precipitates and matrix (<18 dpa).
Vibrothermography is a nondestructive evaluation technique that uses a temperature-sensitive infrared (IR) camera that observes vibration-induced heat generation at defects, such as cracks, to detect and locate defects within a structure.
Cartilage defects treated with type I collagen matrices showed fibro-cartilage tissue generation while defects treated with type II collagen matrices produced hyaline cartilage tissue [ 13].
We attribute this to the generation of defects in the nanofibers, which are known to give rise to peaks in the green part of the spectrum [41].
After the sapphire removal, the thin LED epilayers are very brittle and favorable to generation of defects, thereby, increasing reverse leakage current.
Lack of uniformity and generation of defects including grain boundaries and wrinkles in graphene coatings synthesized using chemical vapour deposition (CVD) adversely affect the durability of these coatings.
