Sentence examples for generation and translocation from inspiring English sources

Based on these data, we have proposed a model wherein the phosphorylation state of APP at Thr668 may govern the state of activation of an intracellular signaling cascade across APP that leads to generation and translocation of AICD, analogous to the well-characterized signaling cascade across Notch that leads to generation and translocation of the Notch intracellular domain [15].

These observations indicate that the generation and translocation of the TRA-2 ICD7 fragment into the nucleus is a biologically relevant event in transcriptional regulations in the case of nematodes.

The parameters involved in the generation and translocation of the NICD (kNICD, KNICD, KRBP-J, kd,NICD, k0,NICD-RBP, kd,NRB) were excluded from this process as they require the presence of an active delta signal which results in a deviation from the oscillatory resting state for which experimental data are available.

In addition, Ang II also induced NADPH oxidase/ROS generation and p47phox translocation from the cytosol to the membrane.

From these observations, we suggest the existence of a novel alternative signaling pathway for mammalian Ptc1 that is mediated by the generation and nuclear translocation of ICD7 fragments.

Based on these observations, we would like to propose a novel signaling pathway for mammalian Ptc1 that is mediated through the generation and nuclear translocation of ICD7 fragments.

We therefore suggest a novel signaling mechanism for mammalian Ptc1 that is mediated by the generation and nuclear translocation of C-terminal ICD7 fragments.

PAR generation and AIF translocation were also detected after AOPPs treatment.

We therefore asked whether UV-induced ROS generation occurred in Chang cells and if treatment with antioxidants such as N-acetyl l-cysteine (NAC) and Mito-Tempo (Enzo Life Sciences, Farmingdale, NY, USA) could reduce UV-induced ROS generation and HMGB1 translocation.

Shedding-dependent activation of signal transduction by EpCAM is perpetuated further by cleavage via the γ-secretase complex, allowing the generation and nuclear translocation of the EpICD (Fig. 2 C ).

Our data demonstrated that mitochondrial uncoupling efficiently prevented TPA-induced mitochondrial ROS generation, and blocked p53 mitochondrial translocation, leading to prevention of mitochondrial dysfunction and attenuation of apoptotic cell death.