Sequence generation, allocation concealment and blinding were assessed using the "risk of bias" tool (Figure 1).
We assessed adequacy of random generation, allocation concealment and masking of assessors.
The RoB tool comprises six domains: sequence generation, allocation concealment, blinding, incomplete outcome data, selective outcome reporting, and "other sources of bias".
The Cochrane RoB tool evaluates six domains including: sequence generation, allocation concealment, blinding, missing outcome data, selective outcome reporting, and "other sources of bias".
In an exploratory analysis, no significant differences were found for adequate reporting of random sequence generation, allocation concealment, blinding and primary outcomes between industry and non-industry RCTs.
Our primary outcomes were the proportion of registry records with adequate reporting of random sequence generation, allocation concealment, blinding, and trial outcomes.
Our protocol included random sequence generation, allocation concealment, and blinding.
25 The tool covers sequence generation, allocation concealment, selective outcome reporting and other sources of bias.
Methods of sequence generation, allocation concealment and information on incomplete outcome data were frequently not reported.
Many RCTs had missing data especially on the domains of sequence generation, allocation concealment and blinding.
Attention toward adequate sequence generation, allocation concealment and complete information for outcome data varied across studies.
