"This was a house to generate controlled dissent, a machine to generate tolerance," Neil MacGregor, the director of the museum, wrote recently in The Art Newspaper.
Also in yeast, mutations that increase activity of the ubiquitin proteasome pathway generate tolerance for aneuploidy (26).
Another set of approaches recently harnessed to generate tolerance with biomaterials exploits the differences in the mechanisms by which soluble and particulate antigens are trafficked in LNs and spleens.
This aging-related decline in immune function is termed immunosenescence and is associated with a decreased capacity to induce protective immunity and generate tolerance towards harmless antigens, suboptimal vaccine efficacy and the increased incidence of tumours and autoimmune diseases.
As well as detecting and destroying pathogens and their toxins, the mucosal immune system must also be able to discriminate between these pathogens and the harmless commensal micro-organisms and food antigens and generate tolerance towards them.
2012), and the generation of antigen-specific populations of Treg cells in response to the commensal microbiota is thought to provide post-thymic education of the immune system and to generate tolerance (Lathrop et al. 2011; Renz, Brandtzaeg and Hornef 2011).
In order to reduce the uncertainty and to support the semantic interoperability in assembly tolerance specification design, an ontology-based approach for automatically generating assembly tolerance types is proposed.
Based on this, an approach for automatically generating assembly tolerance types is proposed.
An application example is provided to illustrate the process of generating assembly tolerance types.
We identified the peritoneal cavity as a site that protects allogeneic lymphocytes from killing by NK cells, and found that systemic chimerism, but not chimerism restricted to the peritoneum, was capable of generating natural tolerance.
