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However to date, the absence of reliable assessment systems that can deliver ICF classification has meant that there has been no means of generating population Ievel ICF data.
However, it is important to emphasize that the sample size of the Shanghai population is appropriate and adequate for generating population genetic estimates [ 58].
It is interesting to hypothesize that rapid genetic variation at these MIRU loci may have effects on the transcription of the regulon, thus generating population diversity.
There was moderate genetic differentiation among all samples (excluding ROS) and the tests for R ST > θ ST [ 49] suggested that mutation has played a minor role in generating population differentiation.
Theory predicts that adaptive mtDNA mutations should fix rapidly within populations through positive selection in females [ 4] and the nuclear genome should co-adapt as a corollary [ 20], generating population differentiation.
These results suggest that either the model is valid and our sample happened to have an extremely unlikely variance, or the model is not valid and something in addition to demographic stochasticity is generating population fluctuations.
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Due to these and other challenges, alternative methods for generating population-representative longitudinal studies to examine child maltreatment are necessary.
Specifically, the Micro-Genetic Algorithm works by generating populations of the missing local correlation parameters.
The Rapid Assessment of Avoidable Blindness (RAAB) survey is a relatively cheap and easy means of generating population-based data on prevalence and causes of blindness in persons aged 50 and over.
Metacyclic promastigotes bound to AnV beads were submitted to magnetic cell separation, generating populations of 70 80% purity in both positive and negative fractions (Fig. S1A).
This system retains the benefits of robustness arising from negative feedback, while simultaneously generating population-level on/off responses thought to be critical for cell fate decisions.
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