Sentence examples for generating differentiated from inspiring English sources

Furthermore, Dicer-null NS cells are incapable of generating differentiated progeny, whereas glioma cells typically can differentiate to neurons or glia in vitro [48].

While modelling the early steps of embryonic development in vitro may provide the best approach for generating differentiated cells with native properties, devising protocols for differentiation of pluripotent stem cells is largely an empirical task.

We next assessed whether cells contained within the neurosphere-like clusters were capable of generating differentiated cells of the three neural lineages: neurons, astrocytes, and oligodendrocytes.

This similarity suggests that provision of weak enhancer activity might also be a normal mechanism for generating differentiated populations in the course of development.

The CD133+/CD 34− phenotype characterizes very primitive peripheral cells, that are capable of generating differentiated cells of the neuroectoderm, as well as liver, lung, brain, heart, gut, and striated muscle cells [28], [73].

To confirm that the cultured basal cells maintained their "in vivo" capacity to function as stem/progenitor cells capable of generating differentiated airway epithelial cell types, the basal cells were plated on ALI culture.

Cells grown in serum and LIF can differentiate: they spontaneously generate differentiated cells in culture because they are heterogeneous with respect to the expression of a variety of pluripotency-associated genes, and hence are heterogeneous in their immediate differentiation potential.

In turn, basal/myoepithelial progenitors generate differentiated myoepithelial cells, whereas luminal progenitors differentiate into ductal luminal cells or generate alveolar luminal cells in response to pregnancy hormones [ 17, 35].

Taken together, these results demonstrate that the phase of the cell cycle during which hESCs initiate their differentiation can influence their capacity to generate differentiated cells and underlines the importance of cell-cycle regulation in the mechanisms controlling cell fate decisions.

Thus, Hoxb1b is not generally required in neuropeithelial progenitors to proliferate or to generate differentiated neurons.

Using human pluripotent stem cells as a source to generate differentiated progenies for regenerative medicine applications has attracted substantial interest during recent years.