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A multitude of bioorthogonal reactions, as well as the ability to perform protein trans-splicing in vivo, might also aid in generating designer chromatin in living cells.
8 The technology lends itself well to generating designer microarrays from targeted sources, for example, from polysaccharides following their partial depolymerization, 42 and from N- and O-glycomes, 43 and in principle from the meta-glycome (a term I use, with instigation from Bernard Henrissat, to mean glycomes of diverse origins).
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Powerful genetic techniques can also be used to generate "designer" cells or organisms.
These findings suggest pathways to generate designer nanocomposites for advanced electrically-active applications.
Many organisms across the range of biological complexity have already been edited in this way to generate designer bacteria, plants and primates.
The capability to generate designer DNA architectures with precise spatial control has allowed scientists and engineers to explore novel applications in various fields, including structural biology, DNA computing, nanorobotics, disease diagnosis, and drug delivery.
Pseudotyping, using AAV serotype 2 terminal repeats to generate designer shells capable of transducing selected cell types, enables the packaging of common genomes into multiple serotypes virions to directly compare gene expression and tropism.
The immediate goal of future research will be to generate "designer" strains of entomopathogenic fungi that are more efficient biocontrol agents than currently used wild type strains for specific insect infestations and defined environmental conditions.
63 In order to prove that Dectin-1 binds to carbohydrates rather than to any polypeptides associated with the fungal cell walls and to identify the ligand structure(s), we generated designer probes, that is, NGLs, derived from oligosaccharides up to 13 mers isolated from partially depolymerized ligand-positive and ligand-negative glucan polysaccharides.
The method supports a designer in generating design alternatives that increase the rate by conducting impact analysis with the change of material composition and end-of-life scenario.
To close the loop for supporting designers in generating design concepts flexibly, fast, and easily, an ontology-based approach for knowledge management that works along with the graphical modeling tool is discussed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com