Sentence examples for generating compounds from inspiring English sources

We demonstrate how this model can execute a range of tasks such as generating analogues to a query structure and generating compounds predicted to be active against a biological target.

Finally, when tuning the model towards generating compounds predicted to be active against the dopamine receptor type 2, the model generates structures of which more than 95% are predicted to be active, including experimentally confirmed actives that have not been included in either the generative model nor the activity prediction model.

Unfortunately, the application of this design strategy to generating compounds that can inhibit the amyloid toxicity linked to Alzheimer's and other neurodegenerative diseases has been frustratingly slow.

Superoxide generating compound pyrogallol mimicked the effects of angiotensin II.

Removing the moiety (generating compound E67-2) has no effect on the potency against KIAA1718 but, unexpectedly, lost inhibition against G9a-like protein by a factor of 1500.

This possibility might be answered by generating compound mutant mice in which both isoforms are simultaneously inactivated in the brain.

We first determined the effect of the O2.− generating compound PQ2+ on aconitase activity, H2O2 production, mitochondrial Fe2+ accumulation and cell death in primary midbrain cultures.

Therefore we suggest that DNA replication slippage is the predominant mechanism generating compound microsatellites.

We observed that Δ nop-1 mutants are resistant to the ROS generating compound menadione.

To test the susceptibility spectrum of the mutants, we used plates with gradients of hypochlorite, peroxynitrite, hydrogen peroxide, and the superoxide generating compound menadione (Fig. 1A).

Without this type of complexity, generation would be impossible; since generation in fact occurs, form and matter must be genuine features of generated compounds.