Open image in new window Fig. 3 An example of Paxos members' information used to generate committed LSN.
Given the stem cell-like properties of ESP cells as presented here and reported elsewhere [5], [6], it is tempting to speculate that ESP cells may generate committed progenitor cells through asymmetrical cell division, which, in turn, may lose the SP phenotype, further behave as transient amplifying cells, and eventually propagate through symmetrical cell division.
It relies on small populations of specified precursor cells that expand and generate committed cells, which ultimately differentiate into myocytes.
By dividing asymmetrically, cancer stem cells maintain the stem cell pool and simultaneously generate committed cells that form tumor mass [ 32].
We here observe that the inability of FOG-1-deficient HSCs to generate committed Mk/E progenitors is associated with their loss of preMegE-specific gene expression and upregulation of preGM-associated genes.
Satellite cells, that are normally quiescent, can be activated to proliferate and generate committed progeny in response to a variety of stimuli, including degenerative muscle diseases (Brack and Rando, 2012; Dhawan and Rando, 2005; Rudnicki et al., 2008).
Adult tissues retain a small subset of resident undifferentiated stem cells that can self-renew asymmetrically to generate committed progenitors for the replenishment of the different cellular phenotypes that are lost during normal tissue turnover.
In response to UB signals, induced MM cells acquire an epithelial phenotype (mesenchymal to epithelial transition; MET) to generate committed nephron progenitor populations and sequentially form the pretubular aggregate, renal vesicle and C- and S-shaped bodies that expand to give rise to the mature nephron (Pleniceanu et al, 2010).
The renewal is achieved by a pool of asymmetrically dividing stem/progenitor cells located in the proliferative compartment of the crypt, which guarantees the preservation of multipotent daughter cells, while generating cells committed to differentiation along the crypt luminal axis.
