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We show how cells carrying ISs are often eliminated by the population even with the possibility of generating advantageous mutations.
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The failure of GVAX to support cooperativity between CTLA-4 blockade and 4-1BB activation does not appear to result from an inability to generate advantageous effector to Treg ratios.
It was designed with the aim to quickly generate advantageous initial configurations.
Paradoxically, such errors can generate advantageous phenotypic diversity in fungi and bacteria through poorly understood molecular processes.
However, transposition bursts create genetic diversity which occasionally generates advantageous mutations and thus help organisms adapt to new environments.
On the other hand there are instances where noise in protein expression is exploited by cells to generate advantageous non-genetic variability in cellular phenotype [ 12, 45- 47].
However, to ensure an evolutionary future for new kinases, novel substrate connections need to arise and the balance with competing phosphatases must be tuned to generate advantageous networks that support the ever-elaborating diversity of life.
This is extremely advantageous for the development of statistical models, or rather for generating generally acceptable, stable and plausible estimations of model effects (Tables 1 and 2).
Therefore, tissue engineering may be advantageous for generating urethral grafts.
Increment detection could be advantageous in generating receptor-triggered calcium oscillations.
These results suggest that the antitumour efficacy of iTSCM cells is equivalent to that of TWS119-induced TSCM-like cells; however, coculture with OP9-DL1 is advantageous in generating a larger number of antigen-specific TSCM-like cells.
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