We use this model to generate a repository of in silico granulomas and then "treat" these granulomas with isoniazid (INH) and rifampin (RIF), alone and in combination.
We generated a repository of 500 in silico granulomas, capturing inter-patient variability on a granuloma scale by varying host immune and PK parameters within ranges given in Additional file 1: Tables S1 and S2.
We generate a repository of 500 in silico granulomas, simulate treatment according to current CDC regimens (Fig. 1b), and calculate both average antibiotic concentrations and bacterial numbers for each granuloma over time.
Thus, in order to systematically study co-occurrence patterns in gene expression signatures, we have generated a repository of published gene expression signatures, PubLiME (published lists of microarray experiments, available at http://bio.ifom-ieo-campus.it/publime) (Finocchiaro et al. 2007).
The Cancer Genome Atlas (TCGA) Research Network performed a multifaceted molecular and genomic analysis on over 200 GBM specimens, generating a valuable repository for understanding gliomagenesis.
Generating a population-based repository is a complex and costly task; however only such a repository provides information on the prevalence and allows to analyse predictors for infection in the general population.
Second, for generating such a repository, a novel complete system for floor plan analysis is presented.
Towards this end, we developed a workflow to (1) generate a pilot repository of HLA allele-specific peptide spectral and assay libraries, and to (2) analyze SWATH-MS HLA peptidomic data acquired from multiple international laboratories.
It's the equivalent of a buried treasure chest of computer generated art: a repository of 100 stunning generative artworks built with Processing, assembled by Matt Pearson.
