A big, local infrastructure project might generate a pause in investment as private actors assess how their business models may change, but growth may eventually be stronger than previously expected (though certainly, some spending won't meet desired cost-benefit goals).
To generate a dependable SD-mediated set of pause sites, we filtered out pause codons for which we could not identify an upstream SD-like element.
Our results rule out the hypothesis of a role of BK channels in generating the pause, as we found the pause to be longer in BK−/− than in WT PCs, and unchanged following paxilline microinjection.
The hypothesis is that for less engaging videos, students are more likely to skip part of the video and search for information that is useful to them, generating more pause and search events and shorter view events.
Because mt-replication frequently pauses at the 3′ end of the CR, PMM would be triggered to generate a new copy or motif indels in existing mtTRs.
We have also characterized the features of promoters that generate the pause using a base-pair resolution run-on assay that we developed called PRO-seq.
Their tracks show that they are fully capable of performing extended forward crawls but that these runs follow a circular path without sharp redirections generated by pause turns, and as a consequence, robo mutant larvae remain within a limited region of the available substrate.
Right now I'm taking a pause from generating new videos to fix up some bugs in Videogrep.
The current model hypothesizes that (1) the interplay between IN and PC generates the PC pause and (2) that the slow-activating mGluR-mediated [Ca2+]i change in PC [48], [49] and in IN [28] determine the timing of the pause.
Nishimura, K. et al. Manipulation of KLF4 expression generates iPSCs paused at successive stages of reprogramming.
The results show that upon SD exclusion, the slow-down in this region was nearly abolished suggesting that the SD motif is necessary to generate the observed pauses.
