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Another benefit of coupling systems-biology models with databases, and a corresponding advance of our model, is that generating a constraint-based model from a database that has associated web-based visualization tools leads to a literate model (by analogy to Knuth's notion of literate programming [ 18]).
The foundations to generate a Constraint Satisfaction Problem (CSP) from a PN are given.
This may generate a constraint on the harmonizing measurement techniques [ 52].
To generate a constraint set for network inference, we excluded the proteomic entities that do not respond to at least a single perturbation condition from the network models.
Nonsynonymous (d N ) and synonymous (d S ) substitution rates for 48 plastid-encoded rpl32 sequences and three nuclear-encoded sequences (rpl32 from Bruguiera was not used in the rate variation estimation because there were insufficient plastid data to generate a constraint tree) were calculated in PAML v.4.8 [ 61] using codeml option with codon frequencies estimated with an F3 × 4 model.
If we denote GDS as the given data set and consider the background knowledge BK, we can use GDS and BK to filter out the inconsistent constraints in CS, and generate a filtered constraint set FCS: (2) FCS = { c | c ∈ CS, c s.
This requirement, however, generates a space constraint to accommodate additional elements.
The Genesis II condylar constrained implant generates a rotational constraint with the consequence of rotational load acting at the tibial post.
Using this approach the chord and pitch distributions of the original blade are varied under geometrical constraints, generating a population of over 200000 different possible individuals.
Semidefinite programming (SDP) relaxation can be used to convert the aforementioned problem into a convex optimization problem by dropping the rank constraint, consequently generating a local optimum [18].
The expansion of ICE families relying on different IS related DDE transposases highlights that transposition via a circular intermediate overcomes these constraints by generating a molecular substrate compatible with the conjugative transfer.
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