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The solution to these essential questions will be effective in generating a competent PHE response.
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This generates a competent case base when processing existing cases.
One main concern is the possibility that reconstruction of standard virus by recombination between two defective genomes would generate a competent virus able to replicate and cause disease.
This fusion generated a competent 14-3-3 14-3-3 14-3-3in shown binding-3 overlay of cell lysates.
Based on the superposition (middle), we predict that the MCM subunits need to approach each other more closely to generate a competent ATPase site.
In our research, we have assumed that the cutaneous phenotype represents a best attempt by a metabolically-compromised epidermis to generate a competent permeability barrier in the desiccating, terrestrial environment (op. cit).
Based on comparison of the ATPase site with the tight 'ATP-like' configuration of E1 (Enemark and Joshua-Tor, 2006), we expect MCM subunits must approach more closely to generate a competent ATPase site.
On the other hand, PDT-treated FaDu cells exhibited profound decreases in the promoter activity (P=0.008) as well as viral replication (P=0.011), although the cells were capable of generating a replication competent virus.
W347, along with R372, also appears to be a key player in generating a catalytically competent active site since mutation of either residue decreases activity to near background levels.
Notably, these compounds bind a form of PAD4 that lacks calcium at the Ca2 site, mimicking our calcium titration data with PAD2, and again highlighting the importance of Ca2 for generating a catalytically competent conformation.
This cleavage event results in structural rearrangements in which the nonpolar N-terminus amino acids of HA2 (the fusion peptide) are repositioned to the interior of the trimer, thereby burying the ionizable residues in the cleaved HA and generating a fusion competent structure [ 45].
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