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This function generates null communities by randomly assembling them from the observed species pool.
The procedure generates null genotype configurations from which null statistics are calculated and a null empirical distribution created.
When testing a single hypothesis, a valid procedure generates null P values that are distributed uniformly between 0 and 1.
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Scientifically, I challenge the notion that we need to standardize methods to generate null alleles.
Randomization tests can be applied to data in order to generate null distributions non-parametrically.
The indel mutations were confirmed by Sanger sequencing (Supplementary Fig. 2b, c) and are predicted to create an early frameshift and generate null alleles.
We used insertional mutagenesis to develop a screening method to generate null alleles in a human cell line haploid for all chromosomes except chromosome 8.
Repeated attempts to generate null mutants failed thus indicating that LdAceCS is essential for the parasite and can be selectively targeted to combat Leishmania infection.
Finally, we generated null alleles of HP1a using optimized parameters through homology-directed repair and achieved an overall mutagenesis rate significantly higher than previously reported.
To further characterize c30f12.4, we sought to generate null alleles using CRISPR/Cas9 technology with dual sgRNAs.
The generated null space vectors are normalized vectors, which could avoid the noise amplification problem efficiently.
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